Cough symptom severity in patients with refractory or unexplained chronic cough: a systematic survey and conceptual framework

Cough symptom severity in patients with refractory or unexplained chronic cough: a systematic survey and conceptual framework

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Background Cough severity represents an important subjective endpoint in assessing the effectiveness of therapies for patients with chronic cough.Although cough-specific quality of life questionnaires exist, a widely available cough severity instrument with established measurement properties remains unavailable.Aims To identify and summarise the results of studies reporting on the experience of patients with chronic cough and, in the process, develop a conceptual framework to inform development of a patient-reported outcome measurement (PROM) addressing cough severity.Results We identified 61 eligible studies reporting on seattle seahawks socks patient experience with chronic cough.Studies provided 82 potential items, of which 43 animed blue lotion topical spray proved unique and relevant to cough severity.

The urge-to-cough sensation and the cough symptom itself represented broad domains of cough severity.Two subdomains under urge-to-cough included frequency (1 item) and intensity (1 item).Five subdomains under cough symptoms included control (2 items), frequency (6 items), bout duration (1 item), intensity (8 items), and associated features/sequelae (24 items).Conclusions Our systematic survey and conceptual framework identified items and domains of cough severity in patients with refractory or unexplained chronic cough.The results support item generation and content validity for a PROM assessing cough severity.